Genes, Chromosomes & Cancer will offer rapid publication of original full-length research articles, perspectives, reviews and letters to the editors on genetic analysis as related to the study of neoplasia. The main scope of the journal is to communicate new insights into the etiology and/or pathogenesis of neoplasia, as well as molecular and cellular findings of relevance for the management of cancer patients. While preference will be given to research utilizing analytical and functional approaches, descriptive studies and case reports will also be welcomed when they offer insights regarding basic biological mechanisms or the clinical management of neoplastic disorders. Specific areas covered will include: Mutations at the gene and genome levels in benign and malignant disorders Impact of mutations and genomic rearrangements on gene structure and regulation Consequences of genomic abnormalities for cell proliferation and differentiation Correlations between genomic changes and cellular phenotype Using molecular abnormalities to re-evaluate pathologic classifications The diagnostic and predictive value of alterations at the chromosomal and DNA levels in disease prognosis and in designing and monitoring cancer therapies Molecular and epidemiologic studies of inherited disorders predisposing to cancer Impact of mutational landscape in predicting sensitivity to cancer immunotherapies Novel methods for genomic analysis Evaluation of key aspects related to the wide applicability of NGS in clinical practice

Wiley Online Library 杂志社旗下 基因，染色体和癌症 将迅速发表有关研究与瘤形成相关的原始全长研究文章，观点，评论和有关遗传分析的编辑信。该杂志的主要范围是交流有关肿瘤形成的病因和/或发病机理以及与癌症患者管理相关的分子和细胞发现的新见解。尽管将优先采用分析和功能方法进行研究，但当描述性研究和病例报告提供有关基本生物学机制或赘生性疾病临床治疗的见解时，也将受到欢迎。 涵盖的具体领域包括： 良性和恶性疾病中基因和基因组水平的突变 突变和基因组重排对基因结构和调控的影响 基因组异常对细胞增殖和分化的影响 基因组变化与细胞表型之间的相关性 使用分子异常重新评估病理学分类 染色体和DNA水平改变在疾病预后以及设计和监测癌症治疗中的诊断和预测价值 易患癌症的遗传性疾病的分子和流行病学研究 突变格局对癌症免疫疗法敏感性预测的影响 基因组分析的新方法 与NGS在临床实践中广泛适用性相关的关键方面的评估。