Aging Cell is a bi-monthly peer-reviewed, open access journal that aims to publish the highest quality, innovative research addressing fundamental issues in the biology of aging. For publication in Aging Cell, the work must provide a major new contribution to the understanding of aging and be of general interest to the community. Aging Cell seeks to cover all areas of geroscience, highlighting research that uncovers mechanistic aspects of the aging process, as well as the links between aging and age-related disease. Observations of novel aging processes without substantial mechanistic insight will be considered, but should be of especially high impact for the field. Topics including, but not limited to, nutrient-responsive signaling pathways, neuronal and endocrine signaling pathways, tissue interactions, genetic and epigenetic regulation and integrity, proteostasis, circadian rhythms, ROS and mitochondria, cellular senescence, stem cells, progerias and interventions that affect aging are encouraged. All experimental approaches, including plant models, are welcome. Papers that focus on the pathogenesis of a specific age-related pathology are also of interest, but should offer new insights into the fundamental links between aging and disease. Aims and Scope Aging Cell welcome submissions in the following areas: Genetics and functional genomics: mutations affecting longevity; gene homologies; organismal and cellular aging; gene manipulation. Signaling and gene expression: mechanisms linking age-associated changes with phenotypes and physiology; intracellular signaling; interactions between cells and tissues; hormonal, immune, and inflammatory systems. Cell proliferation, aging and death: replicative senescence; apoptosis; telomere biology and other intrinsic and extrinsic influences; chronological cellular aging; phenotypes of aging cells. Cell stress and damage: extrinsic and intrinsic influences of free radicals on cells and tissues; free radical defense and damage; free radicals as signaling molecules; stress and aging. Stem cells and aging: effects of age on stem cell generation; migration and homeostasis; stem cell-niche interactions; regulatory mechanisms. Integrative physiology: outcomes of aging processes at organismal, cellular and molecular levels. Biodemography and comparative studies: population and cross-species comparative studies. New theories of aging and longevity: discussion at the broadest level of established and novel theories of aging and longevity.

《衰老细胞》 是一本双月刊，经过同行评审的开放获取期刊，旨在发表最高质量的创新研究，以解决衰老生物学中的基本问题。为了在《衰老细胞》中发表，该作品必须为理解衰老提供新的重大贡献，并引起社会普遍关注。老化细胞力图涵盖老年医学的所有领域，着重研究揭示衰老过程机理的研究，以及衰老与年龄相关疾病之间的联系。在没有实质性机械学见识的情况下，将考虑对新的老化过程进行观察，但对该领域的影响特别大。主题包括但不限于营养应答信号通路，神经元和内分泌信号通路，组织相互作用，遗传和表观遗传调控和完整性，蛋白稳态，昼夜节律，ROS和线粒体，细胞衰老，干细胞，早衰和影响干预措施鼓励衰老。欢迎所有实验方法，包括植物模型。关注与特定年龄相关的病理机制的论文也很有趣， 目的和范围 老化单元在以下领域的欢迎意见： 遗传学和功能基因组学：影响寿命的突变；基因同源性 机体和细胞老化；基因操纵。 信号和基因表达：将与年龄有关的变化与表型和生理联系起来的机制；细胞内信号；细胞与组织之间的相互作用；激素，免疫和炎性系统。 细胞增殖，衰老和死亡：复制性衰老；细胞凋亡 端粒生物学及其他内在和外在影响；按时间顺序的细胞衰老；衰老细胞的表型。 细胞应激和损伤：自由基对细胞和组织的外在和内在影响；自由基防御和伤害；自由基作为信号分子；压力和老化。 干细胞与衰老：年龄对干细胞生成的影响；迁移和体内平衡；干细胞与生态位的相互作用；监管机制。 综合生理学：在生物，细胞和分子水平上衰老过程的结果。 生物人口学和比较研究：人口和跨物种比较研究。 衰老和长寿的新理论：在建立和新颖的衰老和长寿理论的最广泛层面上进行讨论。